Synthesis and neuropharmacological activity of some quinoxalinone derivatives
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Academic Journals
2018
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| Онлайн хандалт: | https://ir.oauife.edu.ng/handle/123456789/3735 |
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| _version_ | 1810764574296637440 |
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| author | Olayiwola, G. Obafemi, C.A. Taiwo, F.O |
| author_facet | Olayiwola, G. Obafemi, C.A. Taiwo, F.O |
| author_sort | Olayiwola, G. |
| collection | DSpace |
| description | 11 |
| format | Article |
| id | oai:ir.oauife.edu.ng:123456789-3735 |
| institution | My University |
| language | English |
| publishDate | 2018 |
| publisher | Academic Journals |
| record_format | dspace |
| spelling | oai:ir.oauife.edu.ng:123456789-37352023-05-13T11:10:22Z Synthesis and neuropharmacological activity of some quinoxalinone derivatives Olayiwola, G. Obafemi, C.A. Taiwo, F.O Quinoxalin-2-ones quinoxaline-2,3-diones sedative effect anticonvulsant activity anxiolytic activity 11 Eight quinoxalinone derivatives were synthesized and investigated for some neuropharmacological effects (analgesia, sedation, convulsion, anxiety, memory and psychosis) in mice and rats. In the CNS depressant activity, N,N-dibenzyl-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-sulfonamide is the most active, while the other compounds appear variously dose-dependent. Only three of the compounds showed anxiolytic effect, with N,N-dibenzyl-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-sulfonamide showing the highest activity at 2.5 mg/kg. At the dose of 30 mg/kg, 6-nitro-1,4-dihydroquinoxaline-2,3-dione showed a better anxiolytic effect in mice than diazepam (dose: 1 mg/kg), while 1,2,3,4-tetrahydroquinoxaline-2,3-dione (dose: 25 mg/kg) showed a comparative effect to diazepam. 6-Chloro-1,4-dihydro-quinoxaline-2,3-dione and N,N-dibenzyl-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-sulfonamide showed significant anticonvulsant action. None of the compounds showed any analgesic or antidopaminergic effect. The LD50 (24 h) calculated for the compounds were between 74 and 160 mg/kg i.p. 2018-11-30T18:52:26Z 2018-11-30T18:52:26Z 2007-03-19 Article Olayiwola et al. (2007) Synthesis and neuropharmacological activity of some quinoxalinone derivatives. African Journal of Biotechnology 6 (6):777-786 1684–5315 https://ir.oauife.edu.ng/handle/123456789/3735 en application/pdf Academic Journals |
| spellingShingle | Quinoxalin-2-ones quinoxaline-2,3-diones sedative effect anticonvulsant activity anxiolytic activity Olayiwola, G. Obafemi, C.A. Taiwo, F.O Synthesis and neuropharmacological activity of some quinoxalinone derivatives |
| title | Synthesis and neuropharmacological activity of some quinoxalinone derivatives |
| title_full | Synthesis and neuropharmacological activity of some quinoxalinone derivatives |
| title_fullStr | Synthesis and neuropharmacological activity of some quinoxalinone derivatives |
| title_full_unstemmed | Synthesis and neuropharmacological activity of some quinoxalinone derivatives |
| title_short | Synthesis and neuropharmacological activity of some quinoxalinone derivatives |
| title_sort | synthesis and neuropharmacological activity of some quinoxalinone derivatives |
| topic | Quinoxalin-2-ones quinoxaline-2,3-diones sedative effect anticonvulsant activity anxiolytic activity |
| url | https://ir.oauife.edu.ng/handle/123456789/3735 |
| work_keys_str_mv | AT olayiwolag synthesisandneuropharmacologicalactivityofsomequinoxalinonederivatives AT obafemica synthesisandneuropharmacologicalactivityofsomequinoxalinonederivatives AT taiwofo synthesisandneuropharmacologicalactivityofsomequinoxalinonederivatives |