Pharmacological analysis of the Neuromuscular properties of Diethylcarbamazine citrate in Vitro.
101p
Đã lưu trong:
| Tác giả chính: | |
|---|---|
| Định dạng: | Luận văn |
| Ngôn ngữ: | Tiếng Anh |
| Được phát hành: |
Obafemi Awolowo University
2019
|
| Những chủ đề: | |
| Truy cập trực tuyến: | https://ir.oauife.edu.ng/handle/123456789/4543 |
| Các nhãn: |
Thêm thẻ
Không có thẻ, Là người đầu tiên thẻ bản ghi này!
|
| _version_ | 1810764572739502080 |
|---|---|
| author | Olayiwola, Gbola |
| author_facet | Olayiwola, Gbola |
| author_sort | Olayiwola, Gbola |
| collection | DSpace |
| description | 101p |
| format | Thesis |
| id | oai:ir.oauife.edu.ng:123456789-4543 |
| institution | My University |
| language | English |
| publishDate | 2019 |
| publisher | Obafemi Awolowo University |
| record_format | dspace |
| spelling | oai:ir.oauife.edu.ng:123456789-45432023-05-13T11:29:42Z Pharmacological analysis of the Neuromuscular properties of Diethylcarbamazine citrate in Vitro. Olayiwola, Gbola neuromuscular diethylcarbamazine citrate pharmacological actions DECC biventer-cervicis muscle chick biventer-cervicis 101p The pharmacological actions of diethylcarbamazine citrate (DECC) have been examined in vitro on isolated chick biventer-cervicis muscle preparations. DECC (5x10-1 - 1.5mM) produced a concentration-related initial augmentation of the indirect electrically-evoked twitches followed by a sustained, longer-lasting secondary depression of the twitches of the skeletal muscle-nerve (chick biventer-cervicis) preparations examined. DECC-induced twitch depression was competitively reversed by increasing calcium ion (Ca ) concentration of the bathing fluid. The contractual responses of innervated chick biventor m muscle preparation induced by bathapplied low concentrations (2.5x10-2M) of carbachol, acetylcholine or nicotine was markedly augmented by DECC (10-3 - 2.5x10-2M). This same concentration of DECC (10-3 - 2.5x10- 2M)• also depressed the contra contractual responses of the muscle elicited by high concentrations of the agonists. Relatively high concentrations of DECC (10-1 - 2.5mM) dose dependently contracted isolated chick biventer cervicis muscle preparations, and demonstrated measurable anticholinesterase activity. It is concluded that DECC possesses both direct (postjunctional) and indirect (pre-junctional) effects at the neuromuscular junction, and that the neuromuscular blockade produced by DECC is possibly post-junctional in origin. The clinical significance of the neuromuscular blockade produced by DECC is also discussed. 2019-10-08T17:20:21Z 2019-10-08T17:20:21Z 1985 Thesis Thesis Gbola. O, 1985. Pharmacological analysis of the Neuromuscular properties of Diethylcarbamazine citrate in Vitro. https://ir.oauife.edu.ng/handle/123456789/4543 en application/pdf Obafemi Awolowo University |
| spellingShingle | neuromuscular diethylcarbamazine citrate pharmacological actions DECC biventer-cervicis muscle chick biventer-cervicis Olayiwola, Gbola Pharmacological analysis of the Neuromuscular properties of Diethylcarbamazine citrate in Vitro. |
| title | Pharmacological analysis of the Neuromuscular properties of Diethylcarbamazine citrate in Vitro. |
| title_full | Pharmacological analysis of the Neuromuscular properties of Diethylcarbamazine citrate in Vitro. |
| title_fullStr | Pharmacological analysis of the Neuromuscular properties of Diethylcarbamazine citrate in Vitro. |
| title_full_unstemmed | Pharmacological analysis of the Neuromuscular properties of Diethylcarbamazine citrate in Vitro. |
| title_short | Pharmacological analysis of the Neuromuscular properties of Diethylcarbamazine citrate in Vitro. |
| title_sort | pharmacological analysis of the neuromuscular properties of diethylcarbamazine citrate in vitro |
| topic | neuromuscular diethylcarbamazine citrate pharmacological actions DECC biventer-cervicis muscle chick biventer-cervicis |
| url | https://ir.oauife.edu.ng/handle/123456789/4543 |
| work_keys_str_mv | AT olayiwolagbola pharmacologicalanalysisoftheneuromuscularpropertiesofdiethylcarbamazinecitrateinvitro |