Molecular Characteristics and Antibiotic Resistance Profiles of Klebsiella Isolates in Mthatha, Eastern Cape Province, South Africa
International Journal of Microbiology, Vol. 20, No 17, Article ID 846742, p.1-7.
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International Journal of Microbiology
2020
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| Liŋkkat: | https://ir.oauife.edu.ng/handle/123456789/5131 |
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| author | Vasaikar, Sandeep Obi, Larry Morobe, Isaac Bisi-Johnson, Mary |
| author_facet | Vasaikar, Sandeep Obi, Larry Morobe, Isaac Bisi-Johnson, Mary |
| author_sort | Vasaikar, Sandeep |
| collection | DSpace |
| description | International Journal of Microbiology, Vol. 20, No 17, Article ID 846742, p.1-7. |
| format | Journal |
| id | oai:ir.oauife.edu.ng:123456789-5131 |
| institution | My University |
| language | English |
| publishDate | 2020 |
| publisher | International Journal of Microbiology |
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| spelling | oai:ir.oauife.edu.ng:123456789-51312023-05-13T11:11:24Z Molecular Characteristics and Antibiotic Resistance Profiles of Klebsiella Isolates in Mthatha, Eastern Cape Province, South Africa Vasaikar, Sandeep Obi, Larry Morobe, Isaac Bisi-Johnson, Mary Klebsiella Antibiotic Resistance South Africa Cape Province International Journal of Microbiology, Vol. 20, No 17, Article ID 846742, p.1-7. The increase in the incidence of extended-spectrum 𝛽-lactamase- (ESBL-) producing Klebsiella species has become a serious problem worldwide, because of their incrimination in antibiotic resistance.Theobjective of this study is to investigate the resistance genes responsible for ESBL-producing Klebsiella species and carbapenemase-producing Klebsiella (CRE) isolated in Mthatha and to study their epidemiology. A prospective, descriptive study of 202 nonrepetitive samples frompatients was obtained fromNelson Mandela AcademicHospital.The cultured Klebsiella isolates were subjected to antimicrobial susceptibility tests and the polymerase chain reaction of 𝑏𝑙𝑎CTX-M, 𝑏𝑙𝑎TEM, 𝑏𝑙𝑎SHV, 𝑏𝑙𝑎KPC, and 𝑏𝑙𝑎NDM genes. Overall K. pneumoniae were the majority with 169 (83.7%) species isolates, followed by K. oxytoca with 29 (14.4%), while K. ozaenae and Raoultella ornithinolytica were 2 (0.9%) each. The prevalence of ESBL production in all Klebsiella species was 117 (57.9%). ESBL-genotypic resistance is driven in Mthatha by 𝑏𝑙𝑎SHV 121 (77.1%) followed by 𝑏𝑙𝑎TEM 105 (66.9%) and 𝑏𝑙𝑎CTX-M at 89 (56.7%).The most common ESBL genotype combination among the Klebsiella was 𝑏𝑙𝑎TEM + 𝑏𝑙𝑎SHV + 𝑏𝑙𝑎CTX-M at 79 (50.3%).There is a steady increase in the rate of ESBL genes in the last five years. 2020-01-24T15:45:32Z 2020-01-24T15:45:32Z 2017-01 Journal DOI: 10.1155 https://ir.oauife.edu.ng/handle/123456789/5131 en application/pdf International Journal of Microbiology |
| spellingShingle | Klebsiella Antibiotic Resistance South Africa Cape Province Vasaikar, Sandeep Obi, Larry Morobe, Isaac Bisi-Johnson, Mary Molecular Characteristics and Antibiotic Resistance Profiles of Klebsiella Isolates in Mthatha, Eastern Cape Province, South Africa |
| title | Molecular Characteristics and Antibiotic Resistance Profiles of Klebsiella Isolates in Mthatha, Eastern Cape Province, South Africa |
| title_full | Molecular Characteristics and Antibiotic Resistance Profiles of Klebsiella Isolates in Mthatha, Eastern Cape Province, South Africa |
| title_fullStr | Molecular Characteristics and Antibiotic Resistance Profiles of Klebsiella Isolates in Mthatha, Eastern Cape Province, South Africa |
| title_full_unstemmed | Molecular Characteristics and Antibiotic Resistance Profiles of Klebsiella Isolates in Mthatha, Eastern Cape Province, South Africa |
| title_short | Molecular Characteristics and Antibiotic Resistance Profiles of Klebsiella Isolates in Mthatha, Eastern Cape Province, South Africa |
| title_sort | molecular characteristics and antibiotic resistance profiles of klebsiella isolates in mthatha eastern cape province south africa |
| topic | Klebsiella Antibiotic Resistance South Africa Cape Province |
| url | https://ir.oauife.edu.ng/handle/123456789/5131 |
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