Species and sex differences in the oxidative metabolism of cimetidine and metiamide
149p
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| Aineistotyyppi: | Opinnäyte |
| Kieli: | englanti |
| Julkaistu: |
Obafemi Awolowo University, Ile Ife, Nigeria
2023
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| Linkit: | https://ir.oauife.edu.ng/123456789/5208 |
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| _version_ | 1810764571487502336 |
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| author | Ogundahunsi, Olumide Alade |
| author_facet | Ogundahunsi, Olumide Alade |
| author_sort | Ogundahunsi, Olumide Alade |
| collection | DSpace |
| description | 149p |
| format | Thesis |
| id | oai:ir.oauife.edu.ng:123456789-5208 |
| institution | My University |
| language | English |
| publishDate | 2023 |
| publisher | Obafemi Awolowo University, Ile Ife, Nigeria |
| record_format | dspace |
| spelling | oai:ir.oauife.edu.ng:123456789-52082023-05-13T18:11:48Z Species and sex differences in the oxidative metabolism of cimetidine and metiamide Ogundahunsi, Olumide Alade Metabolism Animals Mammals Oxidation Metabolic conversion Sulphoxide Metabolite 149p The oxidative metabolism of cimetidine (CM) and metiamide (MA) was investigated in seven animal species (one amphibian, two reptiles, one avian and three mammals). Both qualitative and quantitative differences in oxidative metabolism were observed for the two drugs in the different species. C-Oxidation resulting in the formation of 5-hydroxymethyl cimetidine was not detected in toads and lizards, while it was low in tortoise and rats compared to pigeon , cats and rabbits. In the metabolic conversion of CM, the urinary excretion of the sulphoxide and 5-hydroxymethyl CM was significantly different in rats of both sexes treated at two dose levels whereas for MA only the excretion of the sulphoxide metabolite was significantly different (P< 0.01). S- and C- Oxidation of both drugs were found to be dependent on the compound, animal species and their sex. 2023-05-13T16:21:53Z 2023-05-13T16:21:53Z 1985 Thesis https://ir.oauife.edu.ng/123456789/5208 en application/pdf Obafemi Awolowo University, Ile Ife, Nigeria |
| spellingShingle | Metabolism Animals Mammals Oxidation Metabolic conversion Sulphoxide Metabolite Ogundahunsi, Olumide Alade Species and sex differences in the oxidative metabolism of cimetidine and metiamide |
| title | Species and sex differences in the oxidative metabolism of cimetidine and metiamide |
| title_full | Species and sex differences in the oxidative metabolism of cimetidine and metiamide |
| title_fullStr | Species and sex differences in the oxidative metabolism of cimetidine and metiamide |
| title_full_unstemmed | Species and sex differences in the oxidative metabolism of cimetidine and metiamide |
| title_short | Species and sex differences in the oxidative metabolism of cimetidine and metiamide |
| title_sort | species and sex differences in the oxidative metabolism of cimetidine and metiamide |
| topic | Metabolism Animals Mammals Oxidation Metabolic conversion Sulphoxide Metabolite |
| url | https://ir.oauife.edu.ng/123456789/5208 |
| work_keys_str_mv | AT ogundahunsiolumidealade speciesandsexdifferencesintheoxidativemetabolismofcimetidineandmetiamide |