Syntheses, Characterization, Resolution, and Biological Studies of Coordination Compounds of Aspartic Acid and Glycine
International journal of Hindawi Publisher, Volume 2017, 15 pages
-д хадгалсан:
| Үндсэн зохиолчид: | , , , , |
|---|---|
| Формат: | Сэтгүүл |
| Хэл сонгох: | англи |
| Хэвлэсэн: |
Hindawi Publishing
2023
|
| Нөхцлүүд: | |
| Онлайн хандалт: | https://ir.oauife.edu.ng/123456789/5226 |
| Шошгууд: |
Шошго нэмэх
Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!
|
| _version_ | 1810764575355699200 |
|---|---|
| author | Aiyelabola, Temitayo Akinkunmi, Ezekiel Olugbenga Obuotor, Efere Martins Adebajo, Adeleke Clement Isabirye, David |
| author_facet | Aiyelabola, Temitayo Akinkunmi, Ezekiel Olugbenga Obuotor, Efere Martins Adebajo, Adeleke Clement Isabirye, David |
| author_sort | Aiyelabola, Temitayo |
| collection | DSpace |
| description | International journal of Hindawi Publisher, Volume 2017, 15 pages |
| format | Journal |
| id | oai:ir.oauife.edu.ng:123456789-5226 |
| institution | My University |
| language | English |
| publishDate | 2023 |
| publisher | Hindawi Publishing |
| record_format | dspace |
| spelling | oai:ir.oauife.edu.ng:123456789-52262023-05-13T18:07:30Z Syntheses, Characterization, Resolution, and Biological Studies of Coordination Compounds of Aspartic Acid and Glycine Aiyelabola, Temitayo Akinkunmi, Ezekiel Olugbenga Obuotor, Efere Martins Adebajo, Adeleke Clement Isabirye, David Syntheses Characterization Aspartic Acid Glycine Resolution International journal of Hindawi Publisher, Volume 2017, 15 pages Enantiomerically enriched coordination compounds of aspartic acid and racemic mixtures of coordination compounds of glycine metal-ligand ratio 1 : 3 were synthesized and characterized using infrared and UV-Vis spectrophotometric techniques and magnetic susceptibility measurements. Five of the complexes were resolved using (+)- cis -dichlorobis(ethylenediamine)cobalt(III) chloride, (+)-bis(glycinato)(1,10-phenanthroline)cobalt(III) chloride, and (+)-tris(1,10-phenanthroline)nickel(II) chloride as resolving agents. The antimicrobial and cytotoxic activities of these complexes were then determined. The results obtained indicated that aspartic acid and glycine coordinated in a bidentate fashion. The enantiomeric purity of the compounds was in the range of 22.10–32.10%, with (+)- cis -dichlorobis(ethylenediamine)cobalt(III) complex as the more efficient resolving agent. The resolved complexes exhibited better activity in some cases compared to the parent complexes for both biological activities. It was therefore inferred that although the increase in the lipophilicity of the complexes may assist in the permeability of the complexes through the cell membrane of the pathogens, the enantiomeric purity of the complexes is also of importance in their activity as antimicrobial and cytotoxic agents. 2023-05-13T16:26:27Z 2023-05-13T16:26:27Z 2017-02-15 Journal Aiyelabola, Temitayo & Akinkunmi, Ezekiel Olugbenga & Ojo, Isaac & Obuotor, Efere Martins & Adebajo, Adeleke & Isabirye, David. (2017). Syntheses, Characterization, Resolution, and Biological Studies of Coordination Compounds of Aspartic Acid and Glycine. Bioinorganic Chemistry and Applications. 2017. 1-15. 10.1155/2017/2956145 https://ir.oauife.edu.ng/123456789/5226 en application/pdf Hindawi Publishing |
| spellingShingle | Syntheses Characterization Aspartic Acid Glycine Resolution Aiyelabola, Temitayo Akinkunmi, Ezekiel Olugbenga Obuotor, Efere Martins Adebajo, Adeleke Clement Isabirye, David Syntheses, Characterization, Resolution, and Biological Studies of Coordination Compounds of Aspartic Acid and Glycine |
| title | Syntheses, Characterization, Resolution, and Biological Studies of Coordination Compounds of Aspartic Acid and Glycine |
| title_full | Syntheses, Characterization, Resolution, and Biological Studies of Coordination Compounds of Aspartic Acid and Glycine |
| title_fullStr | Syntheses, Characterization, Resolution, and Biological Studies of Coordination Compounds of Aspartic Acid and Glycine |
| title_full_unstemmed | Syntheses, Characterization, Resolution, and Biological Studies of Coordination Compounds of Aspartic Acid and Glycine |
| title_short | Syntheses, Characterization, Resolution, and Biological Studies of Coordination Compounds of Aspartic Acid and Glycine |
| title_sort | syntheses characterization resolution and biological studies of coordination compounds of aspartic acid and glycine |
| topic | Syntheses Characterization Aspartic Acid Glycine Resolution |
| url | https://ir.oauife.edu.ng/123456789/5226 |
| work_keys_str_mv | AT aiyelabolatemitayo synthesescharacterizationresolutionandbiologicalstudiesofcoordinationcompoundsofasparticacidandglycine AT akinkunmiezekielolugbenga synthesescharacterizationresolutionandbiologicalstudiesofcoordinationcompoundsofasparticacidandglycine AT obuotoreferemartins synthesescharacterizationresolutionandbiologicalstudiesofcoordinationcompoundsofasparticacidandglycine AT adebajoadelekeclement synthesescharacterizationresolutionandbiologicalstudiesofcoordinationcompoundsofasparticacidandglycine AT isabiryedavid synthesescharacterizationresolutionandbiologicalstudiesofcoordinationcompoundsofasparticacidandglycine |