Antiproliferative Activities of Fagara xanthoxyloides and Pseudocedrela kotschyi Against Prostate Cancer Cell Lines
Anticancer research,Vol. 35,No. 5,p. 1453–1458
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HHS Public Access
2023
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| Առցանց հասանելիություն: | https://ir.oauife.edu.ng/123456789/5501 |
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| author | KASSIM, OLAKUNLE O. COPELAND, ROBERT L. KENGUELE, HILAIRE M. NEKHAI, SERGEI AKO-NAI, KWASHIE A. KANAAN, YASMINE M. |
| author_facet | KASSIM, OLAKUNLE O. COPELAND, ROBERT L. KENGUELE, HILAIRE M. NEKHAI, SERGEI AKO-NAI, KWASHIE A. KANAAN, YASMINE M. |
| author_sort | KASSIM, OLAKUNLE O. |
| collection | DSpace |
| description | Anticancer research,Vol. 35,No. 5,p. 1453–1458 |
| format | Journal |
| id | oai:ir.oauife.edu.ng:123456789-5501 |
| institution | My University |
| language | English |
| publishDate | 2023 |
| publisher | HHS Public Access |
| record_format | dspace |
| spelling | oai:ir.oauife.edu.ng:123456789-55012023-05-13T18:07:39Z Antiproliferative Activities of Fagara xanthoxyloides and Pseudocedrela kotschyi Against Prostate Cancer Cell Lines KASSIM, OLAKUNLE O. COPELAND, ROBERT L. KENGUELE, HILAIRE M. NEKHAI, SERGEI AKO-NAI, KWASHIE A. KANAAN, YASMINE M. Pseudocedrela kotschyi. Fagara xanthoxyloides prostate cancer Antiproliferative action Anticancer research,Vol. 35,No. 5,p. 1453–1458 Background/Aim—Roots of Fagara zanthoxyloides and Pseudocedrela kotchyii are used as chewing sticks and as medicinal remedies for diarrhea, cough and fever in West Africa. Extracts of the two plants also possess anti-bacterial, anti-fungal and anti-malarial activities. The aim of the present study was to determine the effects of such extracts on the growth, proliferation and induction of apoptosis in four prostate cancer cell lines. Materials and Methods—Androgen-independent PC3 and DU-145 and androgen-dependent LNCaP and CWR-22 prostate cancer cell lines were cultured for five days with different concentrations of the extracts and examined for growth inhibition and evidence of apoptosis. Results—Irrespective of their androgen dependence, all four cancer cell lines exhibited a dosedependent decrease in cell proliferation and viability by the 3-[4,5-dimethylthiazol-2yl]-2,5diphenyltetrazolium bromide (MTT) assay and in induction of apoptosis. The results also show that LNCap cells were the most sensitive to the two extracts, with highest inhibition at day 3 and exhibiting the highest rate of apoptosis. Conclusion—These observations suggest that F. zanthoxyloides and P. kotchyii could serve as potential chemopreventive agents in the treatment of prostate cancer 2023-05-13T17:49:43Z 2023-05-13T17:49:43Z 2015-06-30 Journal https://ir.oauife.edu.ng/123456789/5501 en application/pdf HHS Public Access |
| spellingShingle | Pseudocedrela kotschyi. Fagara xanthoxyloides prostate cancer Antiproliferative action KASSIM, OLAKUNLE O. COPELAND, ROBERT L. KENGUELE, HILAIRE M. NEKHAI, SERGEI AKO-NAI, KWASHIE A. KANAAN, YASMINE M. Antiproliferative Activities of Fagara xanthoxyloides and Pseudocedrela kotschyi Against Prostate Cancer Cell Lines |
| title | Antiproliferative Activities of Fagara xanthoxyloides and Pseudocedrela kotschyi Against Prostate Cancer Cell Lines |
| title_full | Antiproliferative Activities of Fagara xanthoxyloides and Pseudocedrela kotschyi Against Prostate Cancer Cell Lines |
| title_fullStr | Antiproliferative Activities of Fagara xanthoxyloides and Pseudocedrela kotschyi Against Prostate Cancer Cell Lines |
| title_full_unstemmed | Antiproliferative Activities of Fagara xanthoxyloides and Pseudocedrela kotschyi Against Prostate Cancer Cell Lines |
| title_short | Antiproliferative Activities of Fagara xanthoxyloides and Pseudocedrela kotschyi Against Prostate Cancer Cell Lines |
| title_sort | antiproliferative activities of fagara xanthoxyloides and pseudocedrela kotschyi against prostate cancer cell lines |
| topic | Pseudocedrela kotschyi. Fagara xanthoxyloides prostate cancer Antiproliferative action |
| url | https://ir.oauife.edu.ng/123456789/5501 |
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