Polyphenolic compounds with anti-tumour potential from Corchorus olitorius (L.) Tiliaceae, a Nigerian leaf vegetable
25 pages
Salvato in:
| Autori principali: | , , , |
|---|---|
| Natura: | Periodico |
| Lingua: | inglese |
| Pubblicazione: |
2023
|
| Soggetti: | |
| Accesso online: | https://ir.oauife.edu.ng/123456789/5606 |
| Tags: |
Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne!!
|
| _version_ | 1810764575261327361 |
|---|---|
| author | Taiwo, Bamigboye Taiwo, Grace O. Olubiyi, Olujide Oludayo Fatokun, Amos Akintayo |
| author_facet | Taiwo, Bamigboye Taiwo, Grace O. Olubiyi, Olujide Oludayo Fatokun, Amos Akintayo |
| author_sort | Taiwo, Bamigboye |
| collection | DSpace |
| description | 25 pages |
| format | Journal |
| id | oai:ir.oauife.edu.ng:123456789-5606 |
| institution | My University |
| language | English |
| publishDate | 2023 |
| record_format | dspace |
| spelling | oai:ir.oauife.edu.ng:123456789-56062023-05-13T18:07:29Z Polyphenolic compounds with anti-tumour potential from Corchorus olitorius (L.) Tiliaceae, a Nigerian leaf vegetable Taiwo, Bamigboye Taiwo, Grace O. Olubiyi, Olujide Oludayo Fatokun, Amos Akintayo Corchorus olitorius Tiliaceae caffeoyl quinate ferrulic anhydride cytotoxicity 25 pages Chromatographic fractionation of the methanolic extract of Corchorus olitorious (L.) (Tiliaceae), on silica gel yielded two polyphenolic compounds. The structures of the compounds were elucidated as Methyl-1,4,5-tri-O-caffeoyl quinate and Trans-3-(4-Hydroxy- 3-methoxyphenyl) acrylic anhydride, based on extensive use of spectroscopic techniques such as 1H and 13C NMR, DEPT and 2D NMR experiments (COSY, HSQC, HMBC), IR and MS. To establish an initial proof-of-concept for the biological relevance of these compounds, their cytotoxicity in the HeLa cell line was assessed as an index of their anti-tumour potential. The compounds when tested at a range of concentrations up to 1.6 mM were found to possess mild cytotoxic activity. The trans-3-(4-hydroxy-3-methoxyl phenyl) acrylic anhydride was found to be related to curcumin, a compound known to have anti-cancer activity. The plant therefore represents a source of natural ‘lead’ compounds with anti-tumour potential 2023-05-13T18:01:21Z 2023-05-13T18:01:21Z 2016-06 Journal https://ir.oauife.edu.ng/123456789/5606 en application/pdf |
| spellingShingle | Corchorus olitorius Tiliaceae caffeoyl quinate ferrulic anhydride cytotoxicity Taiwo, Bamigboye Taiwo, Grace O. Olubiyi, Olujide Oludayo Fatokun, Amos Akintayo Polyphenolic compounds with anti-tumour potential from Corchorus olitorius (L.) Tiliaceae, a Nigerian leaf vegetable |
| title | Polyphenolic compounds with anti-tumour potential from Corchorus olitorius (L.) Tiliaceae, a Nigerian leaf vegetable |
| title_full | Polyphenolic compounds with anti-tumour potential from Corchorus olitorius (L.) Tiliaceae, a Nigerian leaf vegetable |
| title_fullStr | Polyphenolic compounds with anti-tumour potential from Corchorus olitorius (L.) Tiliaceae, a Nigerian leaf vegetable |
| title_full_unstemmed | Polyphenolic compounds with anti-tumour potential from Corchorus olitorius (L.) Tiliaceae, a Nigerian leaf vegetable |
| title_short | Polyphenolic compounds with anti-tumour potential from Corchorus olitorius (L.) Tiliaceae, a Nigerian leaf vegetable |
| title_sort | polyphenolic compounds with anti tumour potential from corchorus olitorius l tiliaceae a nigerian leaf vegetable |
| topic | Corchorus olitorius Tiliaceae caffeoyl quinate ferrulic anhydride cytotoxicity |
| url | https://ir.oauife.edu.ng/123456789/5606 |
| work_keys_str_mv | AT taiwobamigboye polyphenoliccompoundswithantitumourpotentialfromcorchorusolitoriusltiliaceaeanigerianleafvegetable AT taiwograceo polyphenoliccompoundswithantitumourpotentialfromcorchorusolitoriusltiliaceaeanigerianleafvegetable AT olubiyiolujideoludayo polyphenoliccompoundswithantitumourpotentialfromcorchorusolitoriusltiliaceaeanigerianleafvegetable AT fatokunamosakintayo polyphenoliccompoundswithantitumourpotentialfromcorchorusolitoriusltiliaceaeanigerianleafvegetable |