Effect of Drug Pre-Treatment on The Metabolism of Methyrapone .
135P
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| Formaat: | Thesis |
| Taal: | Engels |
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Obafemi Awolowo University
2023
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| Online toegang: | https://ir.oauife.edu.ng/123456789/5636 |
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| _version_ | 1810764575246647296 |
|---|---|
| author | Okereke, Samuel Emeka |
| author_facet | Okereke, Samuel Emeka |
| author_sort | Okereke, Samuel Emeka |
| collection | DSpace |
| description | 135P |
| format | Thesis |
| id | oai:ir.oauife.edu.ng:123456789-5636 |
| institution | My University |
| language | English |
| publishDate | 2023 |
| publisher | Obafemi Awolowo University |
| record_format | dspace |
| spelling | oai:ir.oauife.edu.ng:123456789-56362023-05-13T18:10:57Z Effect of Drug Pre-Treatment on The Metabolism of Methyrapone . Okereke, Samuel Emeka Drug Metyrapone Cimetidine N-oxides 135P Metyrapone (SU 488), an inhibitor of 11β - hydroxylase used an a diagnostic and therapeutic agent in the treatment of Cushing's disease, has been found to be metabolised in vivo in rats mainly to metyrapol via reductive mechanism and to the N.-oxides in oxidative mechanism. A significant sex difference as to the production of metyrapol was observed; being higher in the male rats (94 ± 1%) than in the female (64 ± 2%). The influence of drug pretreatment on the metabolism of metyrapone was inventigated in the rats. It was observed that phenobarbital, ethanol and pregnenolone significantly (P< 0.05) caused an induction of the metyrapone N-oxide (B) in the male rats while anthracene did not cause any significant induction. Only ethanol significantly (P<0.05) induced the production of N-oxide A. On the other hand cimetidine a cytochrome P- 450 inhibitor and methimazole, an FAD (flavine Adenine dinucleotide) mediated inhibitor of cytochrome P-450, inhibited the formation of Noxide (13) and slight increase in metyropol formation ccmpared to that produced in the inducers. In the female rats, only phenobarbital significantly (P < 0.05) induced the production of both Noxides with a significant decrease in amount of metyrapol formed. While anthracene has no effect on the formation of both N-oxides of metyrapone, (though with increase in amount of metyrapol formed), ethanol, cimetidine and methimazole inhibited the production of metyrapone N-oxide (B) and (A) with a preferential increase in the amount of metyrapol formed. These then suggest a possibility of both FAD and cytochrome P-450 influence in the oxidative metabolism of metyrapon 2023-05-13T18:03:40Z 2023-05-13T18:03:40Z 1985 Thesis Okereke,S.E ( 1985) Effect of drug pre-treatment on the metabolism of methyrapone https://ir.oauife.edu.ng/123456789/5636 en application/pdf Obafemi Awolowo University |
| spellingShingle | Drug Metyrapone Cimetidine N-oxides Okereke, Samuel Emeka Effect of Drug Pre-Treatment on The Metabolism of Methyrapone . |
| title | Effect of Drug Pre-Treatment on The Metabolism of Methyrapone . |
| title_full | Effect of Drug Pre-Treatment on The Metabolism of Methyrapone . |
| title_fullStr | Effect of Drug Pre-Treatment on The Metabolism of Methyrapone . |
| title_full_unstemmed | Effect of Drug Pre-Treatment on The Metabolism of Methyrapone . |
| title_short | Effect of Drug Pre-Treatment on The Metabolism of Methyrapone . |
| title_sort | effect of drug pre treatment on the metabolism of methyrapone |
| topic | Drug Metyrapone Cimetidine N-oxides |
| url | https://ir.oauife.edu.ng/123456789/5636 |
| work_keys_str_mv | AT okerekesamuelemeka effectofdrugpretreatmentonthemetabolismofmethyrapone |